4-[a-(4-Cyanophenyl)-hydroxymethyl]-benzonitrile(ForLetrozole)
Bis(4-cyanophenyl)methanol
CAS: 134521-16-7
Molecular Formula: C15H10N2O
4-[a-(4-Cyanophenyl)-hydroxymethyl]-benzonitrile(ForLetrozole) - Names and Identifiers
| Name | Bis(4-cyanophenyl)methanol |
| Synonyms | 4,4'-dicyanobenzhydrol 4,4'-Dicyanobenzhydrol Bis(4-cyanophenyl)methanol BIS(4-CYANOPHENYL)METHANOL 4,4'-(hydroxymethanediyl)dibenzonitrile 4-[A-(4-CYANOPHENYL)-HYDROXYMETHYL]-BENZONITRILE 4-[α-(4-cyanophenyl)-hydroxymethyl]-benzonitrile 4-[alpha-(4-Cyanophenyl)hydroxymethyl]benzonitrile Bis-(4-cyanophenyl)methanol (Letrazole metabolite) 4-[a-(4-Cyanophenyl)-hydroxymethyl]-benzonitrile(ForLetrozole) 4-[α-(4-Cyanophenyl)-hydroxymethyl]-benzonitrile ( For Letrozole ) |
| CAS | 134521-16-7 |
| InChI | InChI=1/C15H10N2O/c16-9-11-1-5-13(6-2-11)15(18)14-7-3-12(10-17)4-8-14/h1-8,15,18H |
4-[a-(4-Cyanophenyl)-hydroxymethyl]-benzonitrile(ForLetrozole) - Physico-chemical Properties
| Molecular Formula | C15H10N2O |
| Molar Mass | 234.25 |
| Density | 1.27±0.1 g/cm3(Predicted) |
| Melting Point | 158-159 °C |
| Boling Point | 473.5±45.0 °C(Predicted) |
| Flash Point | 240.139°C |
| Solubility | Chloroform (Slightly), Methanol (Slightly) |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | White powder |
| Color | Light Brown |
| pKa | 12.80±0.20(Predicted) |
| Storage Condition | Sealed in dry,Room Temperature |
| Stability | Light Sensitive |
| Refractive Index | 1.644 |
4-[a-(4-Cyanophenyl)-hydroxymethyl]-benzonitrile(ForLetrozole) - Risk and Safety
| HS Code | 29269090 |
4-[a-(4-Cyanophenyl)-hydroxymethyl]-benzonitrile(ForLetrozole) - Introduction
Bis (4-cyanophenyl) methanol is an organic compound with the chemical formula C15H10N2O. The following is an introduction to its nature, use, formulation and safety information:
Nature:
Bis (4-cyanophenyl) methanol is a colorless to yellow powdery solid. It is relatively stable at room temperature, but can be decomposed at high temperatures. Its melting point is about 113-114 degrees Celsius. It is less soluble in water, but soluble in organic solvents such as ethanol and dichloromethane.
Use:
Bis (4-cyanophenyl) methanol is widely used in organic synthesis. It is often used in the preparation of other organic compounds, such as dyes, drugs, pesticides and polymer materials. It can also participate as a ligand in transition metal-catalyzed reactions, such as the synthesis of fused aromatic compounds.
Preparation Method:
Bis (4-cyanophenyl) methanol can be obtained by reacting phenylacetic acid with cyanogen chloride. The specific preparation method includes reacting phenylacetic acid with cyanogen chloride in an appropriate solvent, and the product can be crystallized and purified to obtain the target product.
Safety Information:
Bis (4-cyanophenyl) methanol is relatively stable under general operating conditions, but contact with skin and eyes should be avoided. Wear appropriate protective gloves and eye protection during operation. Care should be taken to avoid contact with strong oxidants and high temperature sources during handling and storage to prevent decomposition or dangerous reactions. If there is an accident, immediately rinse with plenty of water, and seek medical help. When using bis (4-cyanophenyl) methanol, the relevant safety procedures should be observed.
Nature:
Bis (4-cyanophenyl) methanol is a colorless to yellow powdery solid. It is relatively stable at room temperature, but can be decomposed at high temperatures. Its melting point is about 113-114 degrees Celsius. It is less soluble in water, but soluble in organic solvents such as ethanol and dichloromethane.
Use:
Bis (4-cyanophenyl) methanol is widely used in organic synthesis. It is often used in the preparation of other organic compounds, such as dyes, drugs, pesticides and polymer materials. It can also participate as a ligand in transition metal-catalyzed reactions, such as the synthesis of fused aromatic compounds.
Preparation Method:
Bis (4-cyanophenyl) methanol can be obtained by reacting phenylacetic acid with cyanogen chloride. The specific preparation method includes reacting phenylacetic acid with cyanogen chloride in an appropriate solvent, and the product can be crystallized and purified to obtain the target product.
Safety Information:
Bis (4-cyanophenyl) methanol is relatively stable under general operating conditions, but contact with skin and eyes should be avoided. Wear appropriate protective gloves and eye protection during operation. Care should be taken to avoid contact with strong oxidants and high temperature sources during handling and storage to prevent decomposition or dangerous reactions. If there is an accident, immediately rinse with plenty of water, and seek medical help. When using bis (4-cyanophenyl) methanol, the relevant safety procedures should be observed.
Last Update：2024-04-09 15:17:51
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